Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1 		0.300 ModifyingMutation disease RGD Involvement of mutation-based inhibition of beta-catenin phosphorylation at Ser33 in the malignant progression of lung (pre)neoplastic lesions induced by N-nitrosobis(2-hydroxypropyl)amine in male Fischer 344 rats. 17639448 2007
Entrez Id: 1786
Gene Symbol: DNMT1
DNMT1 		0.300 ModifyingMutation disease RGD Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. 21163286 2011
Entrez Id: 1788
Gene Symbol: DNMT3A
DNMT3A 		0.280 ModifyingMutation disease RGD Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. 21163286 2011
Entrez Id: 2067
Gene Symbol: ERCC1
ERCC1 		0.600 GenomicAlterations disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2 		0.500 GenomicAlterations disease CGI
Entrez Id: 5728
Gene Symbol: PTEN
PTEN 		0.400 GenomicAlterations disease CGI
Entrez Id: 253260
Gene Symbol: RICTOR
RICTOR 		0.330 GenomicAlterations disease CGI
Entrez Id: 894
Gene Symbol: CCND2
CCND2 		0.300 GenomicAlterations disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors. 22798288 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. 12460919 2002
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.700 CausalMutation disease CLINVAR
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. 19238210 2009
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. 24035431 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Molecular characterization of acquired resistance to the BRAF inhibitor dabrafenib in a patient with BRAF-mutant non-small-cell lung cancer. 23524406 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918 2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer. 23833300 2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1. 22773810 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.700 CausalMutation disease CGI
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR A patient with BRAF V600E lung adenocarcinoma responding to vemurafenib. 22743296 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. 22608338 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib. 22649091 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. 21483012 2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Genetic predictors of MEK dependence in non-small cell lung cancer. 19010912 2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.700 CausalMutation disease CLINVAR Mutations of the BRAF gene in human cancer. 12068308 2002